Movement Disorders Restless Legs Syndrome
نویسندگان
چکیده
The pathogenesis of idiopathic restless legs syndrome (iRLS) is not well established, but the most important hypothesis suggests dopaminergic dysfunction and iron deficiency. However, recent reports suggest a possible role for several neurotransmitters or neuromodulators, such as aspartate, glutamate, gamma-hydroxybutyric acid (GABA) and opiates, as well as relation with vitamin D deficiency. In this review, we summarise the studies related to neurochemical findings in iRLS.
منابع مشابه
Ferric carboxymaltose in patients with restless legs syndrome and nonanemic iron deficiency: A randomized trial
BACKGROUND Compromised iron status is important in restless legs syndrome pathophysiology. We compared the efficacy and tolerability of ferric carboxymaltose (single intravenous dose) versus placebo for restless legs syndrome treatment in iron-deficient nonanemic patients. METHODS Patients with moderate to severe restless legs syndrome and serum ferritin < 75 μg/L (or serum ferritin 75-300 μg...
متن کاملRestless legs syndrome.
Restless legs syndrome is a common neurologic movement disorder that affects approximately 10 percent of adults. Of those affected with this condition, approximately one third have symptoms severe enough to require medical therapy. Restless legs syndrome may be a primary condition, or it may be secondary to iron deficiency, renal failure, pregnancy, or the use of certain medications. The diagno...
متن کامل1. Introduction Restless Legs Syndrome (rls) Is a Sensorimotor Dis- Order Characterized Primarily by Motor Restless- Ness Which Is Brought on by Rest and Accentuated Later in the Day and during the Early Night in Those with Normal Circadian Activity
This paper reviews evidence from April, 1998 through April 2002 for the dopaminergic treatment of the restless legs syndrome (RLS) and periodic limb movement disorder (PLMD). There has been increased study of dopaminergic agents for the treatment of these conditions since publication of a review paper and practice parameters that covered all types of medical treatment of RLS and PLMD in 1999. F...
متن کاملRestless Legs Syndrome Presenting As Acute Form in a Patient with Guillain-Barre Syndrome
Restless Legs Syndrome (RLS) is a sleep-associated movement disorder with sensory and motor components that follows a chronic course. Acute development of RLS has rarely been reported. Our purpose was to raise awareness of the subject by describing a picture of acute RLS in a case of Guillain-Barre syndrome. Citation: Vildan Altunayoglu Cakmak., et al. “Restless Legs Syndrome Presenting As Acut...
متن کاملSecondary periodic limb movement disorder and restless legs syndrome.
Periodic limb movement disorder (PLMD) and restless legs syndrome (RLS) are well-known entities from a clinical and polysomnographic point of view. PLMD and RLS are seen mostly as primary or hereditary diseases, but may occur in conjunction to other diseases such as uremia, polyneuropathy, Parkinson's disease, and deficiencies of iron and magnesium. This review will discuss the prevalence, etio...
متن کاملرابطه کمبود آهن و سندرم پاهای بیقرار در بیماران تحت همودیالیز
Introduction: Restless legs syndrome is a neurological disorder hemodialysis patients seem to suffer more from this syndrome. Although the pathophysiology of restless legs syndrome is still unknown, assessment of factors associated with this syndrome can help to develop medical knowledge in this field. The present study assessed the relationship between restless legs syndrome, serum iron, and s...
متن کامل